Abstract
Management of complicated tooth extractions has become increasingly relevant, as clinicians are expected to minimise surgical complications while preserving the alveolar ridge for predictable implant rehabilitation across a broader range of anatomically and biologically compromised sites. This research aimed to systematise current evidence on risk-adapted extraction strategies and alveolar ridge preservation methods, with emphasis on their translation into implant-oriented clinical outcomes. A comparative analytical literature review was conducted using recent peer-reviewed studies on radiographic planning, coronectomy, socket sealing, ridge preservation, early-healing adjuncts, and perioperative antimicrobial prophylaxis. The synthesis shows that cone-beam computed tomography improves treatment selection for mandibular third molars suspected of proximity to the inferior alveolar nerve, especially when panoramic radiography suggests overlap or contact. It supports the use of coronectomy in selected high-risk cases to reduce neurosensory complications. Evidence on alveolar ridge preservation indicates reduced post-extraction dimensional collapse, with the clearest clinical gains in ridge width and in posterior maxillary sites where preservation lowers the future need for sinus floor augmentation. Socket sealing with n-butyl-2-cyanoacrylate provides outcomes comparable to collagen membrane sealing in selected clinical situations while simplifying handling. Platelet-rich fibrin improves early recovery indicators, particularly pain and mucosal healing, whereas effects on hard-tissue dimensional outcomes remain inconsistent across protocols. Antibiotic prophylaxis provides limited absolute benefit and supports a selective, risk-based prescribing approach consistent with antimicrobial stewardship. The practical value of this review lies in presenting an integrated clinical pathway that links radiographic risk stratification, selection of extraction technique, ridge preservation, and adjunctive measures to implant-stage feasibility and patient recovery
Keywords:
- Di Spirito F, Caggiano M, Acerra A, Rizki I, Leonetti G, Allegretti G, et al. Re-intervention rate, timing, and indications following coronectomy of the mandibular third molar: A systematic review of systematic reviews. J Clin Med. 2025;14(11):3877. DOI: 10.3390/jcm14113877
- Ruiz-Roca JA, Rodríguez-Molinero JA, Javaloyes-Vicente P, Pereira-Lopes O, Gay-Escoda C. Use of CBCT and panoramic radiography in the prediction of alterations in sensitivity of the inferior alveolar nerve in third molars: A retrospective cross-sectional study. Saudi Dent J. 2024;36(8):1105–10. DOI: 10.1016/j.sdentj.2024.06.001
- Lam L, Ivanovski S, Lee RSB. Alveolar ridge preservation in posterior maxillary teeth for reduction in the potential need for sinus floor elevation procedures: A pilot study. Clin Oral Implants Res. 2024;35(12):1568–84. DOI: 10.1111/clr.14344
- Mahardawi B, Jiaranuchart S, Arunjaroensuk S, Dhanesuan K, Mattheos N, Pimkhaokham A. The clinical benefit of alveolar ridge preservation in the posterior maxilla: A systematic review and meta-analysis. Sci Rep. 2025;15:23019. DOI: 10.1038/s41598-025-06261-w
- Chen K, Chen Y, Chen P, Jiang J, Wang E, Guo C, et al. Is cone beam computed tomography accurate in predicting inferior alveolar nerve exposure during mandibular third molar extraction? BMC Oral Health. 2025;25(1):353. DOI: 10.1186/s12903-025-05716-w
- Kang FW, Yuan XR, Li GC, Yang YFZ, Zhang XM, Hou GY. Coronectomy in lower third molar surgery: A systematic review and meta-analysis. J Oral Maxillofac Surg. 2025;83(5):601–15. DOI: 10.1016/j.joms.2025.01.014
- Fok MR, Pelekos G, Jin L. Efficacy of alveolar ridge preservation in periodontally compromised molar extraction sites: A systematic review and meta-analysis. J Clin Med. 2024;13(5):1198. DOI: 10.3390/jcm13051198
- Wei YP, Han ZY, Hu WJ, Zhang HY, Ren YY, Xu T, et al. Alveolar ridge preservation at molar extraction sites: A systematic review and meta-analysis. J Evid Based Dent Pract. 2025;25(1):102074. DOI: 10.1016/j.jebdp.2024.102074
- Camacho-Alonso F, Águila OGD, Ferrer-Díaz P, Peñarrocha-Oltra D, Guerrero-Sánchez Y, Bernabeu-Mira JC. Cyanoacrylate versus collagen membrane as a sealing for alveolar ridge preservation: A randomized clinical trial. J Funct Biomater. 2024;15(10):279. DOI: 10.3390/jfb15100279
- Aliberti A, Mariniello M, Bergaminelli M, Dolce P, Gargiulo D, Sammartino G, et al. Using injectable platelet-rich fibrin to improve recovery after impacted lower third molar extraction: A randomized controlled clinical trial. Clin Oral Investig. 2025;29:467. DOI: 10.1007/s00784-025-06563-3
- Peixoto AO, Bachesk AB, Leal MOCD, Jodas CRP, Machado RA, Teixeira RG. Benefits of coronectomy in lower third molar surgery: A systematic review and meta-analysis. J Oral Maxillofac Surg. 2024;82(1):73–92. DOI: 10.1016/j.joms.2023.09.024
- Aribau-Gumà C, Jorba-García A, Sánchez-Torres A, Sànchez-Garcés MÀ. Alveolar ridge preservation: An overview of systematic reviews. Int J Oral Maxillofac Surg. 2022;51(2):234–42. DOI: 10.1016/j.ijom.2021.06.002
- López-Valverde N, Macedo de Sousa B, Blanco Rueda JA. Changes of the alveolar bone ridge using bone mineral grafts and collagen membranes after tooth extraction: A systematic review and meta-analysis. Bioengineering (Basel). 2024;11(6):565. DOI: 10.3390/bioengineering11060565
- Dai A, Ding P, Lin R, Mao F, Kang S, Li H, et al. Effect of alveolar ridge preservation at periodontally compromised molar extraction sockets: A retrospective cohort study. J Periodontol. 2025;96(1):9–20. DOI: 10.1002/jper.24-0064
- Hajibagheri P, Basirat M, Tabari-Khomeiran Z, Asadi-Aria A. The efficacy of platelet-rich fibrin (PRF) in post-extraction hard and soft tissue healing and associated complications: A systematic review and meta-analysis of split-mouth randomized clinical trials. BMC Oral Health. 2025;25(1):869. DOI: 10.1186/s12903-025-06238-1
- Ye L, He Y, Ma W, Zhou F, Liu J. Effect of platelet-rich fibrin on the recovery after third molar surgery: A systematic review and meta-analysis. J Craniomaxillofac Surg. 2024;52(10):1095–108. DOI: 10.1016/j.jcms.2024.06.022
- Camps-Font O, Sábado-Bundó H, Toledano-Serrabona J, Valmaseda-de-la-Rosa N, Figueiredo R, Valmaseda-Castellón E. Antibiotic prophylaxis in the prevention of dry socket and surgical site infection after lower third molar extraction: A network meta-analysis. Int J Oral Maxillofac Surg. 2024;53(1):57–67. DOI: 10.1016/j.ijom.2023.08.001
- De Angelis N, Denegri L, Miron IC, Yumang C, Pesce P, Baldi D, et al. Antibiotic prescription for the prevention of postoperative complications after third-molar extractions: A systematic review. Dent J (Basel). 2025;13(3):107. DOI: 10.3390/dj13030107
- Torof E, Morrissey H, Ball PA. The role of antibiotic use in third molar tooth extractions: A systematic review and meta-analysis. Medicina. 2023;59(3):422. DOI: 10.3390/medicina59030422
- Vidović Juras D, Škrinjar I, Križnik T, Andabak Rogulj A, Lončar Brzak B, Gabrić D, et al. Antibiotic prophylaxis prior to dental procedures. Dent J (Basel). 2024;12(11):364. DOI: 10.3390/dj12110364
- Zhurakivska K, Troiano G, Caponio VCA. Balancing individual and community risk: Role of dentists in antimicrobial stewardship. Lancet Microbe. 2025;6(10):101185. DOI: 10.1016/j.lanmic.2025.101185
- Martine C, Sutherland S, Born K, Thompson W, Teoh L, Singhal S. Dental antimicrobial stewardship: A qualitative study of perspectives among Canadian dentistry sector leaders and experts in antimicrobial stewardship. JAC Antimicrob Resist. 2024;6(3):dlae082. DOI: 10.1093/jacamr/dlae082
- Iturbe Cordero AA, Jaramillo AP, Vasquez J. Perioperative antimicrobial prophylaxis for invasive dental procedures: A systematic review and random-effects meta-analysis of randomized and placebo-controlled studies. Cureus. 2026;18(1):e100755. DOI: 10.7759/cureus.100755
- Atieh MA, Shah M, Hakam A, AlAli F, Aboushakra I, Alsabeeha NHM. Alveolar ridge preservation versus early implant placement in single non-molar sites: A systematic review and meta-analysis. Clin Oral Implants Res. 2024;35(9):1055–71. DOI: 10.1111/clr.14314
- Póvoa RCS, Mourão CFAB, Geremias TC, Sacco R, Guimarães LS, Montemezzi P, et al. Does coronectomy a feasible and safe procedure to avoid the inferior alveolar nerve injury during third molars extractions? A systematic review. Healthcare. 2021;9(6):750. DOI: 10.3390/healthcare9060750
- Steel BJ, Surendran KSB, Braithwaite C, Mehta D, Keith DJW. Current thinking in lower third molar surgery. Br J Oral Maxillofac Surg. 2022;60(3):257–65. DOI: 10.1016/j.bjoms.2021.06.016