ISSN 2415-3060 e-ISSN 2522-4972
Article Vol. 10, No. 1, 2025 / Pages: 38-47

Effect of creatine on improving a person’s physical performance: A literature review

28.10.2024 Received
06.01.2025 Revised
06.03.2025 Accepted

Abstract

Creatine is a popular dietary supplement that has a significant impact on physical performance, strength, and endurance, making it relevant for use in sports, rehabilitation, and performance improvement in different age groups. The purpose of the study was to evaluate the effectiveness of creatine use to improve athletic performance, physical endurance, muscle strength, muscle hypertrophy, and functional performance of athletes, people with physical disabilities, and the elderly. The results of numerous experimental studies were analysed, including controlled trials, systematic reviews, and meta-analyses that evaluated the effects of creatine on a person’s physical performance using combined training protocols and various dosing strategies. The conducted studies indicated a high efficiency of creatine use by athletes and people of other professions related to both physical and mental work. It helps to reduce muscle damage and increase the overall performance of athletes, in particular, by increasing phosphocreatine reserves and stimulating anabolic processes. In athletes, creatine helped to increase muscle mass, reduce fatigue, and improve training intensity, regardless of gender. The combination of creatine with other substances has shown additional benefits in increasing strength and endurance. The use of creatine in combination with training contributed to regional muscle hypertrophy, increases their thickness and volume, especially in conditions of restricted blood flow. In older adults, the supplement reduced muscle loss, improved strength and functionality even with low levels of physical activity. Creatine reduced fatigue and improved functional performance in patients with chronic diseases and neurodegenerative conditions. The results poined to the universality of creatine as an effective tool for improving athletic performance, functional performance, and recovery after exercise in various population groups. Its use is recommended for professional athletes, the elderly, and people with special physical needs

Keywords:
dietary supplements; sports performance; physical performance; functional efficiency; muscle strength; muscle hypertrophy

[1] Vargas-Molina S, García-Sillero M, Kreider RB, Salinas E, Petro JL, Benítez-Porres J, et al. A randomized open-labeled study to examine the effects of creatine monohydrate and combined training on jump and scoring performance in young basketball players. J Int Soc Sports Nutr. 2022;19(1):529–42. DOI: 10.1080/15502783.2022.2108683

[2] Almeida D, Pereira R, Borges EQ, Rawson ES, Rocha LS, Machado M. Creatine supplementation improves physical performance, without negative effects on health markers, in young weightlifters. J Sci Sport Exerc. 2022;4(3):255–65. DOI: 10.xxxx/jss-2022-yyyy

[3] Varillas-Delgado D. Association of genetic profile with muscle mass gain and muscle injury prevention in professional football players after creatine supplementation. Nutrients. 2024;16(15):2511. DOI: 10.3390/nu16152511

[4] Gordji-Nejad A, Matusch A, Kleedörfer S, Jayeshkumar Patel H, Drzezga A, Elmenhorst D, et al. Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. Sci Rep. 2024;14(1):4937. DOI: 10.1038/s41598-024-54249-9

[5] Kious BM, Kondo DG, Renshaw PF. Creatine for the treatment of depression. Biomolecules. 2019;9(9):406. DOI: 10.3390/biom9090406

[6] Ostojic SM, Stea TH, Ellery SJ, Smith‐Ryan AE. Association between dietary intake of creatine and female reproductive health: Evidence from NHANES 2017–2020. Food Sci Nutr. 2024;12:4893–8. DOI: 10.1002/fsn3.4135

[7] Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, et al. Common questions and misconceptions about creatine supplementation: What does the scientific evidence really show? J Int Soc Sports Nutr. 2021;18(1):1–17. DOI: 10.1186/s12970-021-00412-w

[8] Lanhers C, Pereira B, Naughton G, Trousselard M, Lesage FX, Dutheilet F. Creatine supplementation and lower limb strength performance: A systematic review and meta-analyses. Sport Med. 2015;45(9):1285–94. DOI: 10.1007/ s40279-015-0337-4

[9] Wang C-C, Fang C-C, Lee Y-H, Yang M-T, Chan K-H. Effects of 4-week creatine supplementation combined with complex training on muscle damage and sport performance. Nutrients. 2018;10(11):1640. DOI: 10.3390/ nu10111640

[10] Kaviani M, Abassi A, Chilibeck PD. Creatine monohydrate supplementation during eight weeks of progressive resistance training increases strength in as little as two weeks without reducing markers of muscle damage. J Sports Med Phys Fit. 2018;59(4):608–12. DOI: 10.23736/S0022-4707.18.08406-2

[11] Sousa-Silva R, Cholewa J, de Araújo Pessôa K, Zhi X, Lauver J, Rossi FE, et al. Creatine supplementation combined with blood flow restriction training enhances muscle thickness and performance: A randomized, placebo-controlled, and double-blind study. Appl Physiol Nutr Metab. 2023;48(6):417–26. DOI: 10.1139/apnm-2022-0209

[12] Korotych V. Assessment of physical (somatic) health of young men in the construction of health improving strength training. Bull Med Biol Res. 2024;6(2):25–37. DOI: 10.61751/bmbr/2.2024.25

[13] Burke R, Piñero A, Coleman M, Mohan A, Sapuppo M, Augustin F, et al. The effects of creatine supplementation combined with resistance training on regional measures of muscle hypertrophy: A systematic review with metaanalysis. Nutrients. 2023;15(9):2116. DOI: 10.3390/nu15092116

[14] Da Silva Azevedo AP, Acquesta FM, Lancha Jr AH, Bertuzzi R, Poortmans JR, Amadio AC, et al. Creatine supplementation can improve impact control in high-intensity interval training. Nutrition. 2019;61:99–104. DOI: 10.1016/j.nut.2018.09.020

[15] Ramírez-Campillo R, González-Jurado JA, Martínez C, Nakamura FY, Peñailillo L, Meylan CM. Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players. J Sci Med Sport. 2016;19(8):682–7. DOI: 10.1016/j.jsams.2015.10.005

[16] Fernández-Landa J, Fernández-Lázaro D, Calleja-González J, Caballero-García A, Córdova Martínez A, LeónGuereño P, et al. Effect of ten weeks of creatine monohydrate plus HMB supplementation on athletic performance tests in elite male endurance athletes. Nutrients. 2020;12(1):193. DOI: 10.3390/nu12010193

[17] Brooks SJ, Candow DG, Roe AJ, Fehrenkamp BD, Wilk VC, Bailey JP, et al. Creatine monohydrate supplementation changes total body water and DXA lean mass estimates in female collegiate dancers. J Int Soc Sports Nutr. 2023;20(1):2193556. DOI: 10.1080/15502783.2023.2193556

[18] Forbes SC, Candow DG., Neto JH, Kennedy MD, Forbes JL, Machado M, et al. Creatine supplementation and endurance performance: Surges and sprints to win the race. J Int Soc Sports Nutr. 2023;20(1):2204071. DOI: 10.1080/15502783.2023.2204071  

[19] Soares Freitas Sampaio CR, Aidar FJ, Ferreira AR, Santos JL, Marçal AC, Matos DG, et al. Can creatine supplementation interfere with muscle strength and fatigue in brazilian national level paralympic powerlifting? Nutrients. 2020;12(9):2492. DOI: 10.3390/nu12092492

[20] Nersesova LS, Petrosyan MS, Arutjunyan AV. Neuroprotective potential of creatine. Hidden resources of its therapeutic and preventive use. Neurochem J. 2022;16(1):14–30. DOI: 10.1134/S1819712422010093

[21] De Benedetto F, Pastorelli R, Ferrario M, de Blasio F, Marinari S, Brunelli L, et al. Supplementation with Qter® and сreatine improves functional performance in COPD patients on long term oxygen therapy. Respir Med. 2018;142:86–93. DOI: 10.1016/j.rmed.2018.08.002

[22] Palomino-Schätzlein M, Lamas-Domingo R, Ciudin A, Gutiérrez-Carcedo P, Marés R, Aparicio-Gómez C, et al. A translational in vivo and in vitro metabolomic study reveals altered metabolic pathways in red blood cells of type 2 diabetes. J Clin Med. 2020;9(6):1619. DOI: 10.3390/jcm9061619

[23] Post A, Groothof D, Schutten JC, Flores‐Guerrero JL, Swarte JC, Douwes RM, et. al. Plasma creatine and incident type 2 diabetes in a general population‐based cohort: The prevend study. Clin Endocrinol. 2021;94(4):563–74. DOI: 10.1111/cen.14396

[24] Oskroba A, Mateusz P, Orzechowska A, Ziętara K, Pawełczak N, Raksaet K, et al. Therapeutic effects of creatine supplementation in patients with type II diabetes. J Educ Health Sport. 2023;16(1):68–73. DOI: 10.12775/ JEHS.2023.16.01.008

[25] Hass CJ, Collins MA, Juncos JL. Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: A randomized trial. Neurorehabil Neural Repair. 2007;21(2):107–15. DOI: 10.1177/1545968306293449

[26] Attia A, Ahmed H, Gadelkarim M, Morsi M, Awad K, Elnenny M, et al. Meta-analysis of creatine for neuroprotection against Parkinson’s disease. CNS Neurol Disord Drug Targets. 2017;16(2):169–75. DOI: 10.2174/1871527315666161104161855

[27] Del Franco A, Ambrosio G, Baroncelli L, Pizzorusso T, Barison A, Olivotto I, et al. Creatine deficiency and heart failure. Heart Fail Rev. 2022;27:1–12. DOI: 10.1007/s10741-021-10173-y

[28] Aron A, Landrum EJ, Schneider AD, Via M, Evans L, Rawson ES. Effects of acute creatine supplementation on cardiac and vascular responses in older men: A randomized controlled trial. Clin Nutr ESPEN. 2024;63:557–63. DOI: 10.1016/j.clnesp.2024.07.008

[29] Gras D, Lanhers C, Bagheri R, Ugbolue UC, Coudeyre E, Pereira B, et al. Creatine supplementation and VO2 max: A systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021;63(21):4855–66. DOI: 10.1080/10408398.2021.2008864

[30] Candow DG, Forbes SC, Chilibeck PD, Cornish SM, Antonio J, Kreider RB. Variables influencing the effectiveness of creatine supplementation as a therapeutic intervention for sarcopenia. Front Nutr. 2019;6:124. DOI: 0.3389/ fnut.2019.00124

[31] Camic CL, Housh TJ, Zuniga JM, Traylor DA, Bergstrom HC, Schmidt RJ, et al. The effects of polyethylene glycosylated creatine supplementation on anaerobic performance measures and body composition. J Strength Cond Res. 2014;28(3):825–33. DOI: 10.1519/jsc.0b013e3182a361a5.

[32] Elstad K, Malone C, Luedke J, Jaime SJ, Dobbs WC, Almonroeder T, et al. The effects of protein and carbohydrate supplementation, with and without creatine, on occupational performance in firefighters. Nutrients. 2023;15(24):5134. DOI: 10.3390/nu15245134

[33] Prokopidis K, Giannos P, Triantafyllidis KK, Kechagias KS, Forbes SC, Candow DG. Effects of creatine supplementation on memory in healthy individuals: A systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2023;81(4):416–27. DOI: 10.1093/nutrit/nuac064

[34] Davies TW, Watson N, Pilkington JJ, McClelland TJ, Azzopardi G, Pearse RM, et al. Creatine supplementation for optimization of physical function in the patient at risk of functional disability: A systematic review and meta-analysis. J Parenter Enter Nutr. 2024;48(4):389–405. DOI: 10.1002/jpen.2607

[35] Seper V, Korovljev D, Todorovic N, Stajer V, Ostojic J, Nesic N, et al. Guanidinoacetate-creatine supplementation improves functional performance and muscle and brain bioenergetics in the elderly: A pilot study. Ann Nutr Metab. 2021;77(4):244–7. DOI: 10.1159/000518499

[36] Chrusch MJ, Chilibeck PD, Chad KE, Davison KS, Burke DG. Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc. 2001;33(12):2111–7. DOI: 10.1097/00005768-200112000-00021

[37] Bernat P, Candow DG, Gryzb K, Butchart S, Schoenfeld BJ, Bruno P. Effects of high-velocity resistance training and creatine supplementation in untrained healthy aging males. Appl Physiol Nutr Metab. 2019;44(11):1246–53. DOI: 10.1139/apnm-2019-0066

[38] Chami J, Candow DG. Effect of creatine supplementation dosing strategies on aging muscle performance. J Nutr Health Aging. 2018;23(3):281–5. DOI: 10.1007/s12603-018-1148-8

[39] Fransen JC, Zuhl M, Kerksick CM, Cole N, Altobelli S, Kuethe DO, et al. Impact of creatine on muscle performance and phosphagen stores after immobilization. Eur J Appl Physiol. 2015;115(9):1877–86. DOI: 10.1007/s00421-0153172-2

[40] Johnston AP, Burke DG, MacNeil LG, Candow DG. Effect of creatine supplementation during castinduced immobilization on the preservation of muscle mass, strength, and endurance J Strength Cond Res. 2009;23(1):116–20. DOI: 10.1519/jsc.0b013e31818efbcc

[41] Balestrino M, Adriano E. Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain and muscle. Med Res Rev. 2019;39(6), 2427–59. DOI: 10.1002/med.21590

[42] Dahal M, Dahal KR, Pokhrel NR, Kutal D. Creatine supplements: What the research says about how it can help healthy athletes. Glob J Health Sci. 2024;16(2):48. DOI: 10.5539/gjhs.v16n2p48

[43] Schäfer LU, Hayes M, Dekerle J. Creatine supplementation improves performance above critical power but does not influence the magnitude of neuromuscular fatigue at task failure. Exp Physiol. 2019;104(12):1881–91. DOI: 10.1113/ ep087886

APA Style
Goldenko, D., Pylypenko, O., & Mandziuk, M. (2025). Effect of creatine on improving a person’s physical performance: A literature review. Ukrainian Journal of Medicine, Biology and Sports, 10(1) , 38-47. https://doi.org/10.63341/ujmbs/1.2025.38
Vancouver Style
Goldenko D, Pylypenko O, Mandziuk M. Effect of creatine on improving a person’s physical performance: A literature review. Ukr J Med Biol Sport. 2025;10(1):38–47. doi:10.63341/ujmbs/1.2025.38

What are you looking for?